E-01
3-Aminocyclobutanone hydrochloride
3-氨基环丁酮盐酸盐
Application
Abrocitinib
CAS No. 1035374-20-9
C₄H₈ClNO
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Therapeutic Area
Immunology & Inflammation
30 intermediates
Area Overview
Immunology & Inflammation Portfolio
Catalog programs in this area include JAK and TYK2 pathway modulators, immune-mediated dermatology candidates, inflammatory-disease programs and other targeted approaches to immune regulation.
Classification is based on terminal APIs in the product catalog; product counts update with the catalog.
Representative Terminal APIs
Lcotrokinra（JNJ-2113） Tofacitinib Belumosudil Abrocitinib Ruxolitinib
30 catalog intermediates
Intermediates for this Area
E-02
3-Oxocyclobutanecarboxylic acid
3-氧代环丁烷甲酸
Application
Abrocitinib
CAS No. 23761-23-1
C₅H₆O₃
E-03
Tert-butyl (3-oxocyclobutyl)carbamate
叔丁基(3-氧代环丁基)氨基甲酸酯
Application
Abrocitinib
CAS No. 154748-49-9
C₉H₁₅NO₃
E-07
2-(1-(Ethylsulfonyl)azetidin-3-ylidene) acetonitrile
2-(1-(乙基磺酰基)氮杂环丁-3-亚基)乙腈
Application
Baricitinib
CAS No. 1187595-85-2
C₇H₁₀N₂O₂S
E-08
1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1-(1-乙氧乙基)-4-(4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-基)-1H-吡唑
Application
Baricitinib / Ruxolitinib
CAS No. 1029716-44-6
C₁₃H₂₃BN₂O₃
E-09
4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-D] pyrimidine
4-氯-7-[2-(三甲基硅基)乙氧基]甲基-7H-吡咯并[2,3-d]嘧啶
Application
Baricitinib / Tofacitinib
CAS No. 941685-26-3
C₁₂H₁₈ClN₃OSi
E-10
1-Boc-5-aminoindazole
1-Boc-5-氨基吲唑
Application
Belumosudil
CAS No. 129488-10-4
C₁₂H₁₅N₃O₂
E-11
2-bromo-N-isopropylacetamide
2-溴-N-异丙基乙酰胺
Application
Belumosudil
CAS No. 75726-96-4
C₅H₁₀BrNO
E-12
N-isopropyl-2-(3-(4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetamide
N-异丙基-2-(3-(4-氧代-3,4-二氢喹唑啉-2-基)苯氧基)乙酰胺
Application
Belumosudil
CAS No. 2121561-39-3
C₁₉H₁₉N₃O₃
E-13
Phenol, 3-(4-chloro-2-quinazolinyl)-, 1-acetate
3-(4-氯-2-喹唑啉基)苯酚乙酸酯
Application
Belumosudil
CAS No. 911417-24-8
C₁₆H₁₁ClN₂O₂
E-14
Brepocitinib
布雷波替尼
Application
Brepocitinib
CAS No. 1883711-97-4
C₁₇H₁₅ClN₆O₂
E-18
Deucravacitinib
氘可来昔替尼
Application
Deucravacitinib
CAS No. 1609392-27-9
C₂₀H₂₂N₈O₃
E-24
4-aminooxane-4-carboxylic acid
4 -氨基四氢吡喃-4-羧酸
Application
Lcotrokinra（JNJ-2113）
CAS No. 39124-20-4
C₆H₁₁NO₃
E-25
7-Methyl-L-tryptophan
L-7-甲基色氨酸
Application
Lcotrokinra（JNJ-2113）
CAS No. 33468-36-9
C₁₂H₁₄N₂O₂
E-26
7-Methylindole
7-甲基吲哚
Application
Lcotrokinra（JNJ-2113）
CAS No. 933-67-5
C₉H₉N
E-27
N-Cbz-L-Glutamic acid 5-tert-butyl ester
N-苄氧羰基-L-谷氨酸-γ-叔丁酯
Application
Lcotrokinra（JNJ-2113）
CAS No. 3886-08-6
C₁₇H₂₃NO₆
E-28
N-Fmoc-7-methyl-L-tryptophan
N-芴甲氧羰基- 7-甲基-L-色氨酸
Application
Lcotrokinra（JNJ-2113）
CAS No. 1808268-53-2
C₂₇H₂₄N₂O₄
E-29
Z-Tyr-Ome
L-酪氨酸甲酯
Application
Lcotrokinra（JNJ-2113）
CAS No. 13512-31-7
C₁₈H₁₉NO₅
E-31
2-(Trimethylsilyl)ethoxymethyl chloride
2-(三甲基硅基)乙氧基甲基氯
Application
Ruxolitinib
CAS No. 76513-69-4
C₆H₁₅ClOSi
E-32
3-Cyclopentyl-acrylonitrile
3-环戊基丙烯腈
Application
Ruxolitinib
CAS No. 591769-05-0
C₈H₁₁N
E-33
Pyrazole-4-boronic acid pinacol ester
吡唑-4-硼酸频哪酯
Application
Ruxolitinib
CAS No. 269410-08-4
C₉H₁₅BN₂O₂
E-34
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
(3R,4R)-1-苄基-N,4-二甲基哌啶-3-胺二盐酸盐
Application
Tofacitinib
CAS No. 1062580-52-2
C₁₄H₂₄Cl₂N₂
E-35
1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
1-苄基-N,4-二甲基哌啶-3-胺二盐酸盐
Application
Tofacitinib
CAS No. 1228879-37-5
C₁₄H₂₄Cl₂N₂
E-36
4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE
4-氯-7-对甲苯磺酰基-7H-吡咯并[2,3-d]嘧啶
Application
Tofacitinib
CAS No. 479633-63-1
C₁₃H₁₀ClN₃O₂S
E-37
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
4-氯-7H-吡咯并[2,3-d]嘧啶
Application
Tofacitinib
CAS No. 3680-69-1
C₆H₄ClN₃
E-38
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
N-甲基-N-((3R,4R)-4-甲基哌啶-3-基)-7H-吡咯并[2,3-d]嘧啶-4-胺
Application
Tofacitinib
CAS No. 477600-74-1
C₁₃H₁₉N₅
E-39
(3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidine carboxylic acid phenylmethyl ester
(3R,4S)-3-(2-溴乙酰基)-4-乙基-1-吡咯烷甲酸苄酯
Application
Upadacitinib
CAS No. 1428243-26-8
C₁₆H₂₀BrNO₃
E-40
tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate
叔丁基5-对甲苯磺酰基-5H-吡咯并[2,3-b]吡嗪-2-基氨基甲酸酯
Application
Upadacitinib
CAS No. 1201187-44-1
C₁₈H₂₀N₄O₄S
E-41
(S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid
(S)-4-(叔丁氧基羰基)-1,4-氧氮杂环庚烷-2-羧酸
Application
Brensocatib
CAS No. 1273567-44-4
C₁₁H₁₉NO₅
E-42
(S)-tert-butyl (1-cyano-2-(4-iodophenyl)ethyl)carbamate
(S)-(1-氰基-2-(4-碘苯基)乙基)氨基甲酸
Application
Brensocatib
CAS No. 1159489-37-8
C₁₄H₁₇IN₂O₂
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